报告题目：
Graded-Bandgap Quantum-Dot-Modified Nanotubes: A Sensitive Biosensor for
Enhanced Detection of DNA Hybridization
时间：周二（11月10日）下午2：30
地点：A722
报告人：上海交通大学冯传良教授

冯传良教授简介：冯传良博士现为上海交通大学教授，主要从事以聚合物高分子作为必要的生物
平台发展在生物分子检测和人体组织工程中的潜在应用的研究。在基于能量传递的敏感生物纳米
反应器和超分子材料在人体组织工程中的应用研究方面取得了斐然的成果。首次发明了控制能量
高效传递的梯度性纳米结构来检测生物DNA分子。曾主持参与荷兰NanoNed对纳米纤维作为仿生
胶原蛋白在人体组织工程中的应用研究项目。冯传良博士2009年8月回国，在上海交通大学金属
基复合材料国家重点实验室成立了人体组织工程实验课题组，开展对低分子量仿生纳米纤维作为
仿生胶原蛋白在人体组织工程中的应用研究。

abstract of his talk:
The functionalization of nanotubes (NTs) is an effective way to design
new hybrid materials by coupling the properties of supramolecular
building blocks or novel nanostructures to NTs, which have attracted
considerable interest as biocatalysts, biosensors, or for bio-separation.
One of the novel approaches to functionalize NTs is to integrate quantum
dots (QDs) with their promising properties, such as narrow emission
bandwidth, photochemical stability, and high quantum yield. However, the
strategies reported so far for producing QD modified NTs gave low
efficiency of the chemical functionalization or non-uniform assembly of
QDs. Therefore, the design of functionalized NTs with multi-
functionalities, e.g. equipped with efficient assembly of fluorescent
labels, bio-linkers, or surface groups providing enhanced
biocompatibility, is key to the successful application of NTs. Here, a
strategy for the design and the fabrication of QD/dendrimer composite NTs
inside AAO membranes with a pore diameter of 400 nm, a lattice constant
of 500 nm and a pore depth of 100 µm is reported . The arrays of aligned
QD/dendrimer composite NTs enabled the detection of DNA hybridisation
with significantly enhanced sensitivity. To this end, the high specific
surface of the pore walls of the AAO membranes, which amounts to about
70,000 µm2 per 10 µm2 membrane surface, is combined with graded band gap
architectures for efficient energy transfer to the inner surfaces of the
NTs, onto which with single-stranded probe DNA is grafted. Thus, the
emission of dye-labeled target DNA can be probed with exceptionally high
sensitivity and selectivity after its hybridization to the probe DNA.